RESEARCH TECHNICIAN/ENGINEER IN BIOANALYSES BY LC-MS/MS | BIOTECH | PARIS

The company has an extensive clinical development program in neurodegenerative disease, oncology and inflammatory diseases.

We are looking for one Research Technician or Engineer in bioanalyses by LC-MS/MS for its new Early ADME/DMPK department.

Missions :

Within a multidisciplinary team in vitro/in vivo biology you will ensure the technical execution of the “Early- ADME/DMPK” studies, which are entrusted to you in compliance with the quality system in force. By joining us, you will be primarily responsible for:

• Develop and validate methods for the determination of small chemical molecules by Ultra High Performance Liquid Chromatography (UHPLC) coupled with LC-MS/MS tandem mass spectrometry;
  
• Perform in vitro biology experiments to evaluate the physico-chemical and ADME properties of molecules from our medicinal chemistry laboratories including:
  
•  Solubility, pKa, LogP, LogD
  
• Permeability/Carriers (Caco-2)
  
• Metabolic stability (microsomes, hepatocytes) o Plasma protein binding
  
• Routine analysis of biological samples from in vivo biological experiments
  
• Determination of the pharmacokinetic parameters of the molecules of interest;
  
• Write/reread procedures;
  
• Participate in the proper functioning of the laboratory, maintenance of the equipment entrusted.
  

Profile :

• Scientific training bac+2/3 to bac+5 in Analytical Chemistry or Biochemistry
  
• Minimum of 2 + years of industrial or academic experience in Bioanalysis on a similar position
  
• Knowledge of LC-MS/MS and sample preparation (solid phase extraction, liquid-liquid extraction) as well as experience in UHPLC analysis with mass spectrometry detection are required on the job and knowledge of equipment maintenance/qualification would be a plus.
  
• Proficient in scientific English and in the use of computer tools (Empower, Mass Lynx, Analyst, Mass Metasite...)
  
• Highly organized and able to work independently
  
• Ability to work on multidisciplinary projects